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Modeling Compound Action Potentials (SimNerv Virtual Electrophysiology)
Modeling Compound Action Potentials (SimNerv Virtual Electrophysiology)
Using the SimNerv electrophysiology platform, I simulated compound action potential recordings from isolated frog peripheral nerves to study how stimulus parameters shape neural signaling. I systematically manipulated stimulus intensity, duration, electrode spacing, and temperature to observe their effects on CAP magnitude, waveform structure, latency, and conduction velocity.
The experiment highlighted how increasing stimulus intensity recruited larger populations of axons, demonstrating graded CAP responses distinct from the all or none firing of single neurons. Conduction velocity calculations revealed accelerated transmission at higher temperatures, reflecting the influence of ion channel kinetics and membrane physiology.
This project strengthened my understanding of neural recruitment, refractory periods, and signal propagation dynamics, and gave me experience in interpreting electrophysiological data within controlled experimental frameworks.
A) The small bowl holds two separate frog nerves. Each one reacts a little differently, so you’ll test them individually. Click the pool to grab a nerve, then place it in the measurement chamber.
B) The measurement chamber is where you’ll record the nerve’s activity. Open or close the lid by clicking on it, always keep it closed during measurements. The red and blue connectors link to the stimulator, and the green and yellow ones go to the oscilloscope. You can move the electrode sliders and adjust the temperature here. Make sure the red and blue electrodes are at least 3–5 mm apart to avoid short circuits.
C) The stimulator sends an electrical pulse to the nerve. You can adjust a few settings like voltage and pulse width
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